Surfactant Protein A Enhances Alveolar

Surfactant protein A enhances apoptotic cell uptake and TGF- 1 release by inflammatory alveolar macrophages

Reidy, Michael F., and Jo Rae Wright. Surfactant protein A enhances apoptotic cell uptake and TGF1 release by inflammatory alveolar macrophages. Am J Physiol Lung Cell Mol Physiol 285: L854–L861, 2003. First published June 6, 2003; 10.1152/ajplung.00439.2002.—The phagocytosis of apoptotic inflammatory cells by alveolar macrophages (AMs) is a key component of inflammation resolution within the a...

Neutrophils Macrophage Phagocytosis of Apoptotic Surfactant Protein A Enhances Alveolar

Rat surfactant protein D enhances the production of oxygen radicals by rat alveolar macrophages.

Rat surfactant protein D (SP-D) was shown to enhance the production of oxygen radicals by rat alveolar macrophages. This enhancement, which was determined by a lucigenin-dependent chemiluminescence assay, was maximal after 18 min at an SP-D concentration of 0.2 micrograms/ml. Surfactant lipids did not influence the stimulation of alveolar macrophages by SP-D, whereas the oxygen-radical producti...

Surfactant protein A enhances the phagocytosis of C1q-coated particles by alveolar macrophages.

Surfactant protein-A (SP-A) plays multiple roles in pulmonary host defense, including stimulating bacterial phagocytosis by innate immune cells. Previously, SP-A was shown to interact with complement protein C1q. Our goal was to further characterize this interaction and elucidate its functional consequences. Radiolabeled SP-A bound solid-phase C1q but not other complement proteins tested. The l...

Pulmonary cytokine gene therapy. Adenoviral-mediated murine interferon gene transfer compartmentally activates alveolar macrophages and enhances bacterial clearance.

, et al. The T/ebp null mouse: thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, andspecific expression of the murine surfactant protein A (SPA) gene is mediated by interactions between the SPA promoter and thyroid transcription factor-1.